Sentinel lymph node biopsy for staging breast cancer
Identifieur interne : 00B383 ( Main/Exploration ); précédent : 00B382; suivant : 00B384Sentinel lymph node biopsy for staging breast cancer
Auteurs : Isabel T. Rubio [États-Unis] ; Soheila Korourian [États-Unis] ; Christopher Cowan [États-Unis] ; David N. Krag [États-Unis] ; Maureen Colvert [États-Unis] ; V. Suzanne Klimberg [États-Unis]Source :
- The American Journal of Surgery [ 0002-9610 ] ; 1998.
Abstract
Background: Determination of axillary nodal status is essential for the staging of breast cancer since nodal status is one of the most important predictors of survival. The objective of this study was to test the hypothesis that the histology of the first draining lymph node (LN) accurately predicts the histology of the rest of the axillary LNs.Methods: Fifty-five patients with operable invasive breast carcinoma and clinically negative axillary lymph nodes were studied. Patients were injected with Technetium-99 (99Tc) sulfur colloid around the primary tumor. A hand-held gamma detector probe was used to identify the sentinel LN (SLN). After the SLN was identified and removed, a level I and II lymphadenectomy was performed.Results: The SLN was identified in 53 (96.3%) of the 55 patients entered into the trial. The sensitivity was 88.2% and the specificity was 100%. The positive predictive value was 100% and the negative predictive value was 94.6%. The accuracy of the study was 96.2%.Conclusions: The SLN biopsy for breast cancer staging is highly accurate in our hands and has the potential to decrease the morbidity and cost of managing patients with breast cancer without compromise of staging.
Url:
DOI: 10.1016/S0002-9610(98)00264-5
Affiliations:
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Suzanne Klimberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C4DD0DA600895650E5F1A49381C1A0ECBB9A1CCE</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0002-9610(98)00264-5</idno><idno type="url">https://api.istex.fr/document/C4DD0DA600895650E5F1A49381C1A0ECBB9A1CCE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005C32</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005C32</idno><idno type="wicri:Area/Istex/Curation">005C32</idno><idno type="wicri:Area/Istex/Checkpoint">003B18</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">003B18</idno><idno type="wicri:doubleKey">0002-9610:1998:Rubio I:sentinel:lymph:node</idno><idno type="wicri:Area/Main/Merge">00BA96</idno><idno type="wicri:Area/Main/Curation">00B383</idno><idno type="wicri:Area/Main/Exploration">00B383</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sentinel lymph node biopsy for staging breast cancer</title><author><name sortKey="Rubio, Isabel T" sort="Rubio, Isabel T" uniqKey="Rubio I" first="Isabel T" last="Rubio">Isabel T. Rubio</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology (ITR, MC, VSK), University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, John L. McClellan Veteran’s Administration Hospital, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author><author><name sortKey="Korourian, Soheila" sort="Korourian, Soheila" uniqKey="Korourian S" first="Soheila" last="Korourian">Soheila Korourian</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology (SK, VSK), University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, John L. McClellan Veteran’s Administration Hospital, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author><author><name sortKey="Cowan, Christopher" sort="Cowan, Christopher" uniqKey="Cowan C" first="Christopher" last="Cowan">Christopher Cowan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology (CC), University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, John L. McClellan Veteran’s Administration Hospital, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author><author><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N" last="Krag">David N. Krag</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery (DNK), University of Vermont, Burlington, Vermont</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Colvert, Maureen" sort="Colvert, Maureen" uniqKey="Colvert M" first="Maureen" last="Colvert">Maureen Colvert</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology (ITR, MC, VSK), University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, John L. McClellan Veteran’s Administration Hospital, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author><author><name sortKey="Klimberg, V Suzanne" sort="Klimberg, V Suzanne" uniqKey="Klimberg V" first="V. Suzanne" last="Klimberg">V. Suzanne Klimberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology (ITR, MC, VSK), University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, John L. McClellan Veteran’s Administration Hospital, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Surgery</title><title level="j" type="abbrev">AJS</title><idno type="ISSN">0002-9610</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">176</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="532">532</biblScope><biblScope unit="page" to="537">537</biblScope></imprint><idno type="ISSN">0002-9610</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9610</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Determination of axillary nodal status is essential for the staging of breast cancer since nodal status is one of the most important predictors of survival. The objective of this study was to test the hypothesis that the histology of the first draining lymph node (LN) accurately predicts the histology of the rest of the axillary LNs.Methods: Fifty-five patients with operable invasive breast carcinoma and clinically negative axillary lymph nodes were studied. Patients were injected with Technetium-99 (99Tc) sulfur colloid around the primary tumor. A hand-held gamma detector probe was used to identify the sentinel LN (SLN). After the SLN was identified and removed, a level I and II lymphadenectomy was performed.Results: The SLN was identified in 53 (96.3%) of the 55 patients entered into the trial. The sensitivity was 88.2% and the specificity was 100%. The positive predictive value was 100% and the negative predictive value was 94.6%. The accuracy of the study was 96.2%.Conclusions: The SLN biopsy for breast cancer staging is highly accurate in our hands and has the potential to decrease the morbidity and cost of managing patients with breast cancer without compromise of staging.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arkansas</li><li>Vermont</li></region></list><tree><country name="États-Unis"><region name="Arkansas"><name sortKey="Rubio, Isabel T" sort="Rubio, Isabel T" uniqKey="Rubio I" first="Isabel T" last="Rubio">Isabel T. Rubio</name></region><name sortKey="Colvert, Maureen" sort="Colvert, Maureen" uniqKey="Colvert M" first="Maureen" last="Colvert">Maureen Colvert</name><name sortKey="Cowan, Christopher" sort="Cowan, Christopher" uniqKey="Cowan C" first="Christopher" last="Cowan">Christopher Cowan</name><name sortKey="Klimberg, V Suzanne" sort="Klimberg, V Suzanne" uniqKey="Klimberg V" first="V. Suzanne" last="Klimberg">V. Suzanne Klimberg</name><name sortKey="Korourian, Soheila" sort="Korourian, Soheila" uniqKey="Korourian S" first="Soheila" last="Korourian">Soheila Korourian</name><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N" last="Krag">David N. Krag</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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